For the first time, The Ultimate Fighter features mixed martial artists from Mexico and Latin America, eight featherweights and eight bantamweights are divided into teams representing Mexico and Latin America and coached by heavyweight champion Cain Velasquez, and his number one contender, Fabricio Werdum. Over the course of twelve weeks, they live in the same house, and train to fight each other in the octagon, with different backgrounds and cultures but with one dream in mind, to win a contract with the UFC.

Team Gastelum and Team Escudero, each composed of eight Latin American fighters from the welterweight and lightweight divisions, will challenge each other to find out who will be the season two winners of The Ultimate Fighter Latin America.

Team Liddell and Team Griffin are composed of 16 lightweight Latin American fighters that will challenge each other to find out who will be the Season 3 winner of The Ultimate Fighter Latin America.